We surmise that results obtained from the experiments described in this section hire writer cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Concentration dependency off currents using solitary salt-choosy pores within the frog facial skin. Characteristics. 1979; 282 (5738): 519-520 PubMed Conceptual | Author Complete Text
It means this new solid results submit from this manuscript are maybe not warranted and i also cannot accept the new manuscript contained in this mode
The newest article writers have clarified a number of the inquiries I elevated inside the my personal earlier review. Regrettably, the major trouble have not been addressed from this revise. As i made in my previous opinion, I deem it impractical that every those factors will likely be fixed simply because of the a number of added sentences. Rather there are still particular practical issues with the fresh construction and you may, really critically, toward study.
It indicates the latest strong findings put forward by this manuscript try maybe not warranted and i never approve new manuscript inside setting
The newest article writers has made clear a number of the inquiries We raised into the my early in the day review. Unfortuitously, all the biggest dilemmas have not been treated through this improve. Whenever i manufactured in my early in the day remark, We consider it unrealistic that every people affairs should be fixed just of the several extra sentences. Rather there are still certain basic concerns into experimental design and you may, extremely critically, to the research.
- Best concern is whenever We implemented the newest breakdown away from the methods in the earlier adaptation it absolutely was you'll be able to so you're able to decode, with almost finest reliability, any arbitrary stimuli brands We selected. Come across to have examples of which reanalysis. It doesn't matter if i imagine your genuine stimulus checked at the a later day otherwise is consistently switching ranging from rule and silence, the decryption is often near to best. This is exactly an indicator that decryption doesn't have anything to complete with the actual stimuli heard because of the Sender it is opportunistically exploiting different enjoys throughout the studies. The brand new control studies new people performed, treating the new stimulus labels, dont target this issue because it suffers from alike situation. Generally, exactly what the classifier is actually allegedly playing with it's time who's introduced since the recording become.
- The reason behind that is presumably the people used low-independent investigation to have training and you can analysis. If in case I'm sure precisely (select part step 3), haphazard sampling one half of data trials from an enthusiastic EEG shade commonly separate investigation. Recurring the study 5 times – the new manage analysis brand new authors did – isn’t an acceptable solution to target so it concern. At random trying to find products away from an occasion collection that has had slow change (like the slow wave hobby you to presumably reigns over these types of recordings significantly less than these scenarios) often invariably consist of good temporal correlations. Come across TemporalCorrelations.jpg set for 2D density histograms and a correlation matrix appearing this.
- Since revised steps area will bring greater detail now, they is still unclear about exactly what studies were utilized. Antique group investigation declaration exactly what research possess (typical articles regarding the data matrix) and you will what findings (usual rows) were utilized. Anything was an element however, typically this is certainly brand new other EEG channels or fMRI voxels an such like. Observations are often time facts. Right here I guess new article authors switched the fresh intense products on a other place using dominant parts research. That isn't mentioned in case the dimensionality try reduced utilizing the eigenvalues. Regardless, I guess the content trials (accumulated on 128 Hz) had been following utilized because findings together with EEG streams turned because of the PCA were utilized just like the enjoys. The new stimulus names was basically tasked as On the otherwise Regarding for each and every test. Some 50% away from samples (and you can brands) ended up being picked randomly to have studies, and rest was used having review. Is it best?